SERIAL RENAL BIOPSY IN POTASSIUM BROMATE INTOXICATION
نویسندگان
چکیده
منابع مشابه
Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.
Potassium bromate (KBrO3) is an oxidizing agent that has been used as a food additive, mainly in the bread-making process. Although adverse effects are not evident in animals fed bread-based diets made from flour treated with KBrO3, the agent is carcinogenic in rats and nephrotoxic in both man and experimental animals when given orally. It has been demonstrated that KBrO3 induces renal cell tum...
متن کاملToxicological Properties of Potassium Bromate
Potassium bromate (KBrO3), used in both the food and cosmetics industry, and a drinking water disinfection byproduct, is a nephrotoxic chemical and rodent carcinogen. As KBrO3 is primarily an oxidizing compound, reactive oxygen and other species generated from bromate have been held responsible for the genotoxic, carcinogenic and toxic effects. Bromate induces primary DNA oxidative damage, muta...
متن کاملAccidental Potassium Bromate Poisoning in Nine Adults
Accidental Potassium bromate poisoning is uncommon in adults, can have varied manifestations in different patients and can sometimes be deceiving. Potassium bromate white powder and oxidizing agent is used predominantly in bakeries as a maturing agent for flour and as a dough conditioner. It is also occasionally used as a neutralizer in hair kits. This paper deals with nine cases of accidental ...
متن کاملSubchronic toxicity evaluation of potassium bromate in Fischer 344 rats.
Male F344 rats were exposed to potassium bromate (KBrO₃) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400 mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, thyroid, and tunica vaginalis). Weekly body weight and water consumption means w...
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Reference 1 is to Campbell's Letter to the Editor and reference 2 is to Pettinger et al., Am J Physiol 225: 234238, 1973. *P < 0.025 compared with value in 3-week-old spontaneously hypertensive rats. nous substrate and did not demonstrate that substrate remained in excess during that entire period, and (2) they did not use angiotensinase inhibitors during incubation. Incidentally, De Jong et al...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1974
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.38.387